butabarbital will lower the extent or result of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Impact of coadministering a robust CYP3A4 inducer with fedratinib has not been researched.Barbiturates ended up 1st learned to obtain health-related use in 1903, when a research at Bayer confirmed barbi